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Organelle
Molecular Sociology

Organelle Molecular Sociology is a research project supported by Leader Research Program of NRF(National Research Foundation). It is expected to provide novel paradigm for unraveling the molecular and social network of organelle crosstalk in the cell and its regulatory tool using small molecules.

Research Background

  • Need to regulate crosstalk between organelles
    Previous studies have mainly focused on the functional analysis of individual proteins in organelles. In addition, conventional research methods have limitations in analyzing dynamic intracellular molecular systems.
     

  • Providing potential therapeutics to alleviate diseases caused by abnormal organelle interactions
    Aberrant organelle interactions of mitochondria, ER and Golgi apparatus disrupt cellular homeostasis, leading to a number of metabolic diseases such as obesity, type 2 diabetes, hypertension, Parkinson disease and ALS.

Research Strategy

  • This study can provide protein structure and binding information profiles related to small molecules discovered from this study
     

  • This study can be applied to the generation of molecular glues, PROTAC and artificial peptides These small molecule-based biochemical reagent tools are expected to uncover unknown molecular mechanisms of organelle interaction that could not be discovered by classical methods.
     

  • This study can provide ‘Organelle Molecular Sociology’ database which includes not only small molecule and its molecular mechanism but also cellular phenotype and pathological model. This database is expected to provide new insights to various biological areas from drug discovery to diagnosis and therapeutic application.

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