Mitochondria and the endoplasmic reticulum form a platform called the mitochondria-associated membrane (MAM), that facilitates communication between the two organelles. The MAM regulates several physiological processes, including calcium transport, lipid synthesis, autophagy, and ER stress.

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Mitochondria and lysosomes which are central organelles of cellular metabolism interact each other to coordinate bidirectional organelle dynamics. In particular, lysosomes directly regulate mitochondrial fission through contact sites. Mitochondria-Lysosome contacts also mediate transport of metabolites, lipids, calcium and iron.  

Membrane contact sites of mitochondria and peroxisomes contribute to β-oxidation of FAs and has the ability to convey information to each other through the release of biological messengers such as ROS, lipids, or other metabolites. In addition, these organelles undergo intimate crosstalk during cellular redox metabolism. 

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The endoplasmic reticulum directly contacts the plasma membrane, play a significant role in regulating Ca2+ signaling and maintaining homeostasis. When Ca2+ levels decrease, the STIM protein interacts with ORAI, initiating Store-Operated Calcium Entry (SOCE). Tethering between the ER and plasma membrane also regulates ion and lipid transport, signal transduction, ER morphology and remodeling.

The direct membrane contact site between the Endoplasmic Reticulum (ER) and Lysosome facilitates transport of ions, cholesterol, lipids. It also influences lysosomal positioning, fission, and the dephosphorylation of lysosome membrane receptors by ER-based phosphatases.

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The endoplasmic reticulum and Golgi interact and play roles in ceramide transport, subcellular localization, activation of lipid reverse exchange, and regulation of protein trafficking. However, many unknowns remain regarding their regulation and role in controlling key functions such as sorting and trafficking and their relevance in physiological and pathological conditions.