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Organelle Proximity
Physiochemical Assessment System
PHASE I
Organelle Proximity Physiochemical Assessment System (OPPAS) is a useful tool for discovering orgnalle interaction regulators. Using OPPAS, the proximity of 6 pairs between organelles can be detected. During PHASE I, we optimized this system using organelle-specific antibodies and successfully discovered several bioactive organelle interaction regulators.
Validation of organelle interaction
regulatory activity
We used three different methods to validate whether a small molecule regulates organelle interaction. Through the validation step in PHASE I, we successfully identified small molecules hits that effectively regulate organelle interaction.
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